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Omega-3 Fatty Acids and Mood Stabilizers Alter Behavioural and Energy Metabolism Parameters in Animals Subjected to an Animal Model of Mania Induced by Fenproporex.
- Source :
-
Molecular neurobiology [Mol Neurobiol] 2017 Aug; Vol. 54 (6), pp. 3935-3947. Date of Electronic Publication: 2016 May 31. - Publication Year :
- 2017
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Abstract
- Studies have shown that changes in energy metabolism are involved in the pathophysiology of bipolar disorder (BD). It was suggested that omega-3 (ω3) fatty acids have beneficial properties in the central nervous system and that this fatty acid plays an important role in energy metabolism. Therefore, the study aimed to evaluate the effect of ω3 fatty acids alone and in combination with lithium (Li) or valproate (VPA) on behaviour and parameters of energy metabolism in an animal model of mania induced by fenproporex. Our results showed that co-administration of ω3 fatty acids and Li was able to prevent and reverse the increase in locomotor and exploratory activity induced by fenproporex. The combination of ω3 fatty acids with VPA was only able to prevent the fenproporex-induced hyperactivity. For the energy metabolism parameters, our results showed that the administration of Fen for the reversal or prevention protocol inhibited the activities of succinate dehydrogenase, complex II and complex IV in the hippocampus. However, hippocampal creatine kinase (CK) activity was decreased only for the reversal protocol. The ω3 fatty acids, alone and in combination with VPA or Li, prevented and reversed the decrease in complex II, IV and succinate dehydrogenase activity, whereas the decrease in CK activity was only reversed after the co-administration of ω3 fatty acids and VPA. In conclusion, our results showed that the ω3 fatty acids combined with VPA or Li were able to prevent and reverse manic-like hyperactivity and the inhibition of energy metabolism in the hippocampus, suggesting that ω3 fatty acids may play an important role in the modulation of behavioural parameters and energy metabolism.
- Subjects :
- Amphetamines
Animals
Antimanic Agents pharmacology
Bipolar Disorder chemically induced
Bipolar Disorder genetics
Citrate (si)-Synthase metabolism
Creatine Kinase metabolism
Disease Models, Animal
Fatty Acids, Omega-3 administration & dosage
Fatty Acids, Omega-3 pharmacology
Gene Expression Regulation drug effects
Lithium administration & dosage
Lithium pharmacology
Lithium therapeutic use
Male
Rats, Wistar
Succinate Dehydrogenase metabolism
Valproic Acid administration & dosage
Valproic Acid pharmacology
Valproic Acid therapeutic use
Antimanic Agents therapeutic use
Behavior, Animal
Bipolar Disorder drug therapy
Bipolar Disorder metabolism
Energy Metabolism drug effects
Fatty Acids, Omega-3 therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1559-1182
- Volume :
- 54
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecular neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 27246566
- Full Text :
- https://doi.org/10.1007/s12035-016-9933-z