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Enhanced copper-mediated (18)F-fluorination of aryl boronic esters provides eight radiotracers for PET applications.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2016 Jun 28; Vol. 52 (54), pp. 8361-4. - Publication Year :
- 2016
-
Abstract
- [(18)F]FMTEB, [(18)F]FPEB, [(18)F]flumazenil, [(18)F]DAA1106, [(18)F]MFBG, [(18)F]FDOPA, [(18)F]FMT and [(18)F]FDA are prepared from the corresponding arylboronic esters and [(18)F]KF/K222 in the presence of Cu(OTf)2py4. The method was successfully applied using three radiosynthetic platforms, and up to 26 GBq of non-carrier added starting activity of (18)F-fluoride.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 52
- Issue :
- 54
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 27241832
- Full Text :
- https://doi.org/10.1039/c6cc03295h