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Topical Anti-Inflammatory and Analgesic Effects of Multiple Applications of S(+)-Flurbiprofen Plaster (SFPP) in a Rat Adjuvant-Induced Arthritis Model.
- Source :
-
Drug development research [Drug Dev Res] 2016 Jun; Vol. 77 (4), pp. 206-11. Date of Electronic Publication: 2016 May 31. - Publication Year :
- 2016
-
Abstract
- Preclinical Research The aim of this study was to evaluate the efficacy of multiple applications of S(+)-flurbiprofen plaster (SFPP), a novel Nonsteroidal anti-inflammatory drug (NSAID) patch, for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis (AIA) model as compared to other NSAID patches. The AIA model was induced by the injection of Mycobacterium butyricum and rats were treated with a patch (1.0 cm × 0.88 cm) containing each NSAID (SFP, ketoprofen, loxoprofen, diclofenac, felbinac, flurbiprofen, or indomethacin) applied to the paw for 6 h per day for 5 days. The pain threshold was evaluated using a flexion test of the ankle joint, and the inflamed paw edema was evaluated using a plethysmometer. cyclooxygenase (COX)-1 and COX-2 inhibition was evaluated using human recombinant proteins. Multiple applications of SFPP exerted a significant analgesic effect from the first day of application as compared to the other NSAID patches. In terms of paw edema, SFPP decreased edema from the second day after application, Multiple applications of SFPP were superior to those of other NSAID patches, in terms of the analgesic effect with multiple applications. These results suggest that SFPP may be a beneficial patch for providing analgesic and anti-inflammatory effects clinically. Drug Dev Res 77 : 206-211, 2016. © 2016 The Authors Drug Development Research Published by Wiley Periodicals, Inc.<br /> (© 2016 The Authors Drug Development Research Published by Wiley Periodicals, Inc.)
- Subjects :
- Administration, Cutaneous
Analgesics administration & dosage
Animals
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Arthritis, Experimental pathology
Cyclooxygenase 1 drug effects
Cyclooxygenase 1 metabolism
Cyclooxygenase 2 drug effects
Cyclooxygenase 2 metabolism
Cyclooxygenase Inhibitors administration & dosage
Cyclooxygenase Inhibitors pharmacology
Edema drug therapy
Flurbiprofen administration & dosage
Humans
Male
Mycobacterium
Pain drug therapy
Pain Threshold drug effects
Rats
Rats, Inbred Lew
Recombinant Proteins
Transdermal Patch
Analgesics pharmacology
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Arthritis, Experimental drug therapy
Flurbiprofen pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-2299
- Volume :
- 77
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Drug development research
- Publication Type :
- Academic Journal
- Accession number :
- 27241582
- Full Text :
- https://doi.org/10.1002/ddr.21314