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Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration.
- Source :
-
Scientific reports [Sci Rep] 2016 May 31; Vol. 6, pp. 26885. Date of Electronic Publication: 2016 May 31. - Publication Year :
- 2016
-
Abstract
- Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there was no recognized overlap in the genetic contribution to AMD and POAG. At genome-wide significance level, only ABCA1 harbors associations to both diseases. Here, we investigated the genetic architecture of POAG and AMD using genome-wide array data. We estimated the heritability for POAG (h(2)g = 0.42 ± 0.09) and AMD (h(2)g = 0.71 ± 0.08). Removing known loci for POAG and AMD decreased the h(2)g estimates to 0.36 and 0.24, respectively. There was evidence for a positive genetic correlation between POAG and AMD (rg = 0.47 ± 0.25) which remained after removing known loci (rg = 0.64 ± 0.31). We also found that the genetic correlation between sexes for POAG was likely to be less than 1 (rg = 0.33 ± 0.24), suggesting that differences of prevalence among genders may be partly due to heritable factors.
- Subjects :
- Aged
Aged, 80 and over
Case-Control Studies
Female
Genome, Human
Genome-Wide Association Study
Glaucoma, Open-Angle pathology
Humans
Macular Degeneration pathology
Male
Middle Aged
Sex Factors
Genetic Loci
Glaucoma, Open-Angle genetics
Macular Degeneration genetics
Models, Genetic
Multifactorial Inheritance
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 27241461
- Full Text :
- https://doi.org/10.1038/srep26885