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Endothelial and Microcirculatory Function and Dysfunction in Sepsis.
- Source :
-
Clinics in chest medicine [Clin Chest Med] 2016 Jun; Vol. 37 (2), pp. 263-75. Date of Electronic Publication: 2016 Mar 04. - Publication Year :
- 2016
-
Abstract
- The microcirculation is a series of arterioles, capillaries, and venules that performs essential functions of oxygen and nutrient delivery, customized to the unique physiologic needs of the supplied organ. The homeostatic microcirculatory response to infection can become harmful if overactive and/or dysregulated. Pathologic microcirculatory dysfunction can be directly visualized by intravital microscopy or indirectly measured via detection of circulating biomarkers. Although several treatments have been shown to protect the microcirculation during sepsis, they have not improved patient outcomes when applied indiscriminately. Future outcomes-oriented studies are needed to test sepsis therapeutics when personalized to a patient's microcirculatory dysfunction.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1557-8216
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinics in chest medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27229643
- Full Text :
- https://doi.org/10.1016/j.ccm.2016.01.009