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Hepatitis B and C serologic profiles of Canadian organ donors and recipients: retrospective 10-year review at a single center.
- Source :
-
Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2016 Aug; Vol. 18 (4), pp. 520-8. Date of Electronic Publication: 2016 Jul 29. - Publication Year :
- 2016
-
Abstract
- Background: Hepatitis C virus (HBV) and hepatitis C virus (HCV) are important causes of hepatitis and can be transmitted from organ donor to recipient. This study aimed to determine HBV and HCV serologic profiles of a population of Canadian solid organ transplant (SOT) donors and recipients, including prevalence of recipient HBV immunity.<br />Methods: Data on age, gender, organ transplanted, and pre-transplant HBV and HCV serology for SOT donors and recipients at a Canadian hospital from 2001 to 2011 were obtained from a transplant database.<br />Results: There were 2455 recipients (2205 adults, 250 children), and 1559 donors. Over 50% of adult and 44% of pediatric recipients were HBV non-immune pre-transplant. Pediatric recipients were more likely to have HBV vaccine immunity than were adult recipients (48.8% vs. 28.9%, P < 0.001). Prevalence of HBV vaccine immunity was highest in renal recipients (48.3% in adult, 63.2% in pediatric recipients). Recipient HBV vaccine immunity increased from 5.8% in 2001 to 44.5% in 2011 (P < 0.001). Of 134 adult recipients with prior HBV infection, 59 (44%) were co-infected with HCV. Only 0.6% of adult non-liver recipients had acute or chronic HBV infection and 3.2% were anti-HCV positive. Only 2 donors had acute or chronic HBV infection, 29 had prior HBV infection, 9 were isolated hepatitis B core antibody positive, and 15 were anti-HCV positive.<br />Conclusions: The prevalence of HBV vaccine immunity in SOT candidates is low, but increased from 2001 to 2011. Opportunities for quality improvement in pre-transplant HBV immunization exist. HCV co-infection is common in recipients with prior HBV infection. Prevalence of HCV infection in non-liver transplant recipients is low.<br /> (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Canada epidemiology
Child
Child, Preschool
Coinfection blood
Coinfection immunology
Coinfection virology
Female
Hepatitis B blood
Hepatitis B immunology
Hepatitis B virology
Hepatitis B Antibodies blood
Hepatitis B Vaccines administration & dosage
Hepatitis B Vaccines immunology
Hepatitis B virus immunology
Hepatitis C blood
Hepatitis C virology
Humans
Infant
Male
Middle Aged
Prevalence
Retrospective Studies
Seroepidemiologic Studies
Serologic Tests
Sex Factors
Tissue Donors
Transplant Recipients
Young Adult
Coinfection epidemiology
Hepacivirus isolation & purification
Hepatitis B epidemiology
Hepatitis B virus isolation & purification
Hepatitis C epidemiology
Organ Transplantation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3062
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Transplant infectious disease : an official journal of the Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 27226204
- Full Text :
- https://doi.org/10.1111/tid.12558