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Varenicline in smokers with diabetes: A pooled analysis of 15 randomized, placebo-controlled studies of varenicline.
- Source :
-
Journal of diabetes investigation [J Diabetes Investig] 2017 Jan; Vol. 8 (1), pp. 93-100. Date of Electronic Publication: 2016 Jul 14. - Publication Year :
- 2017
-
Abstract
- Aims/introduction: Stopping smoking deserves high priority in preventing complications of diabetes; however, only sparse data are available regarding the efficacy of pharmacotherapy in smokers with diabetes. We assessed the efficacy and safety of varenicline in smokers with diabetes who participated in 15 double-blind, randomized, placebo-controlled studies.<br />Materials and Methods: This retrospective pooled analysis included data from smokers of ≥10 cigarettes per day with diabetes. Participants received varenicline 1 mg b.i.d. or placebo for 12 weeks. We examined carbon monoxide-confirmed continuous abstinence rates (CARs) for weeks 9-12, 9-24 and 9-52, and compared safety in participants with and without diabetes.<br />Results: Of 6,771 participants, 323 had diabetes (varenicline n = 162; placebo n = 161). Week 9-12 CAR was higher with varenicline than placebo (43.8% vs 24.8%; odds ratio 2.36, 95% CI 1.47-3.79), as was week 9-24 CAR (27.5% vs 14.4%; odds ratio 2.25, 95% CI 1.27-4.00). Week 9-52 CAR was 18.4% for varenicline and 10.1% for placebo (odds ratio 2.00, 95% CI 0.90-4.49). The most commonly-reported adverse events in participants with diabetes for varenicline vs placebo were: nausea (27.2% vs 8.1%); headache (9.3% vs 9.9%); and insomnia (8.6% vs 5.6%), incidences that were similar in participants without diabetes (29.6% vs 9.7%; 13.4% vs 10.9%; and 11.4% vs 7.1%, respectively). Weight gain in quitters with diabetes (1.7 kg) was similar to that of those without diabetes (2.1 kg).<br />Conclusions: Varenicline was an effective and well-tolerated aid for smoking cessation in individuals with diabetes. Safety was comparable with participants without diabetes.<br /> (© 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Double-Blind Method
Female
Humans
Male
Middle Aged
Nicotinic Agonists adverse effects
Randomized Controlled Trials as Topic
Retrospective Studies
Tobacco Use Disorder complications
Treatment Outcome
Varenicline adverse effects
Young Adult
Diabetes Complications
Nicotinic Agonists therapeutic use
Smoking Cessation methods
Tobacco Use Disorder drug therapy
Varenicline therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2040-1124
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of diabetes investigation
- Publication Type :
- Academic Journal
- Accession number :
- 27223809
- Full Text :
- https://doi.org/10.1111/jdi.12543