Back to Search
Start Over
Mathematical modeling of the circadian dynamics of the neuroendocrine-immune network in experimentally induced arthritis.
- Source :
-
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2016 Aug 01; Vol. 311 (2), pp. E310-24. Date of Electronic Publication: 2016 May 24. - Publication Year :
- 2016
-
Abstract
- The circadian dynamics of important neuroendocrine-immune mediators have been implicated in progression of rheumatoid arthritis pathophysiology, both clinically as well as in animal models. We present a mathematical model that describes the circadian interactions between mediators of the hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines. Model predictions demonstrate that chronically elevated cytokine expression results in the development of adrenal insufficiency and circadian variability in paw edema. Notably, our model also predicts that an increase in mean secretion of corticosterone (CST) after the induction of the disease is accompanied by a decrease in the amplitude of the CST oscillation. Furthermore, alterations in the phase of circadian oscillation of both cytokines and HPA axis mediators are observed. Therefore, by incorporating the circadian interactions between the neuroendocrine-immune mediators, our model is able to simulate important features of rheumatoid arthritis pathophysiology.<br /> (Copyright © 2016 the American Physiological Society.)
- Subjects :
- Adrenocorticotropic Hormone metabolism
Animals
Arthritis, Experimental immunology
Arthritis, Rheumatoid immunology
Corticotropin-Releasing Hormone metabolism
Models, Theoretical
Rodentia
Arthritis, Experimental metabolism
Arthritis, Rheumatoid metabolism
Circadian Rhythm immunology
Corticosterone metabolism
Cytokines immunology
Hypothalamo-Hypophyseal System metabolism
Pituitary-Adrenal System metabolism
Receptors, Glucocorticoid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1555
- Volume :
- 311
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 27221115
- Full Text :
- https://doi.org/10.1152/ajpendo.00006.2016