Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1-C15 fragment.

Authors :: Zambrana J
Romea P
Urpí F
Source :: Organic & biomolecular chemistry [Org Biomol Chem] 2016 Jun 21; Vol. 14 (23), pp. 5219-23. Date of Electronic Publication: 2016 May 24.
Publication Year :: 2016
Abstract: The preparation of an advanced intermediate on route towards the synthesis of tedanolide C is reported here. It is based on the coupling of two fragments of similar size and complexity, which in turn are prepared by highly stereoselective substrate-controlled titanium-mediated aldol reactions from chiral ketones.

Subjects :: Chemistry Techniques, Synthetic
Ketones chemistry
Stereoisomerism
Macrolides chemical synthesis
Macrolides chemistry

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