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Plasma concentrations of oleoylethanolamide and other acylethanolamides are altered in alcohol-dependent patients: effect of length of abstinence.
- Source :
-
Addiction biology [Addict Biol] 2017 Sep; Vol. 22 (5), pp. 1366-1377. Date of Electronic Publication: 2016 May 22. - Publication Year :
- 2017
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Abstract
- Acylethanolamides are a family of endogenous lipid mediators that are involved in physiological and behavioral processes associated with addiction. Recently, oleoylethanolamide (OEA) has been reported to reduce alcohol intake and relapse in rodents but the contribution of OEA and other acylethanolamides in alcohol addiction in humans is unknown. The present study is aimed to characterize the plasma acylethanolamides in alcohol dependence. Seventy-nine abstinent alcohol-dependent subjects (27 women) recruited from outpatient treatment programs and age-/sex-/body mass-matched healthy volunteers (28 women) were clinically assessed with the diagnostic interview PRISM according to the DSM-IV-TR after blood extraction for quantification of acylethanolamide concentrations in the plasma. Our results indicate that all acylethanolamides were significantly increased in alcohol-dependent patients compared with control subjects (p < 0.001). A logistic model based on these acylethanolamides was developed to distinguish alcohol-dependent patients from controls and included OEA, arachidonoylethanolamide (AEA) and docosatetraenoylethanolamide (DEA), providing a high discriminatory power according to area under the curve [AUC = 0.92 (95%CI: 0.87-0.96), p < 0.001]. Additionally, we found a significant effect of the duration of alcohol abstinence on the concentrations of OEA, AEA and DEA using a regression model (p < 0.05, p < 0.01 and p < 0.001, respectively), which was confirmed by a negative correlation (rho = -0.31, -0.40 and -0.44, respectively). However, acylethanolamides were not influenced by the addiction alcohol severity, duration of problematic alcohol use or diagnosis of psychiatric comorbidity. Our results support the preclinical studies and suggest that OEA, AEA and DEA are altered in alcohol-dependence during abstinence and that might act as potential markers for predicting length of alcohol abstinence.<br /> (© 2016 Society for the Study of Addiction.)
- Subjects :
- Adult
Amides
Arachidonic Acids blood
Case-Control Studies
Dehydroepiandrosterone blood
Endocannabinoids blood
Female
Humans
Male
Middle Aged
Oleic Acids blood
Palmitic Acids blood
Polyethylene Glycols
Polyunsaturated Alkamides blood
Stearic Acids blood
Time Factors
Alcohol Abstinence
Alcoholism blood
Ethanolamines blood
Subjects
Details
- Language :
- English
- ISSN :
- 1369-1600
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Addiction biology
- Publication Type :
- Academic Journal
- Accession number :
- 27212249
- Full Text :
- https://doi.org/10.1111/adb.12408