Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.

Authors :: Cadirci E
Halici Z
Yayla M
Toktay E
Bayir Y
Karakus E
Topcu A
Buyuk B
Albayrak A
Source :: Peptides [Peptides] 2016 Aug; Vol. 82, pp. 35-43. Date of Electronic Publication: 2016 May 18.
Publication Year :: 2016
Abstract: This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30mg/kg. 1h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-α and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Anti-Inflammatory Agents administration & dosage
Carrageenan toxicity
Chromans administration & dosage
Gene Expression Regulation drug effects
Humans
Indomethacin administration & dosage
Inflammation chemically induced
Inflammation pathology
Interleukin-6 genetics
Rats
Receptors, G-Protein-Coupled agonists
Receptors, G-Protein-Coupled antagonists & inhibitors
Receptors, G-Protein-Coupled genetics
Tumor Necrosis Factor-alpha genetics
Urotensins genetics
Inflammation drug therapy
Receptors, G-Protein-Coupled metabolism
Urotensins metabolism

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