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Acquired platelet disorders.
- Source :
-
Thrombosis research [Thromb Res] 2016 May; Vol. 141 Suppl 2, pp. S73-5. - Publication Year :
- 2016
-
Abstract
- In contrast to congenital platelet disorders, which are rare, acquired platelet dysfunctions are more common in clinical practice. Their main causes are medications and systemic/hematologic diseases. Typical clinical manifestations are mucosal bleeding, epistaxis, or superficial epidermal bleeding normally of modest entity. In most cases, the molecular mechanisms underlying impaired platelet function are not fully established, making it difficult to optimize patient care. We here provide a short overview of the various forms of acquired platelet disorders, with a particular focus on recent mechanistic studies on platelet dysfunction in von Willebrand disease.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Blood Platelet Disorders blood
Blood Platelet Disorders complications
Blood Platelets metabolism
Hemostasis
Humans
Liver Diseases blood
Liver Diseases metabolism
Myeloproliferative Disorders blood
Myeloproliferative Disorders metabolism
Uremia blood
Uremia metabolism
von Willebrand Diseases blood
von Willebrand Diseases metabolism
Blood Platelet Disorders etiology
Blood Platelet Disorders metabolism
Blood Platelets pathology
Liver Diseases complications
Myeloproliferative Disorders complications
Uremia complications
von Willebrand Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 1879-2472
- Volume :
- 141 Suppl 2
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 27207431
- Full Text :
- https://doi.org/10.1016/S0049-3848(16)30371-1