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Novel aspects of platelet factor XIII function.
- Source :
-
Thrombosis research [Thromb Res] 2016 May; Vol. 141 Suppl 2, pp. S17-21. - Publication Year :
- 2016
-
Abstract
- Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-2472
- Volume :
- 141 Suppl 2
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 27207415
- Full Text :
- https://doi.org/10.1016/S0049-3848(16)30356-5