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Follicular dendritic cell tumour/sarcoma: a commonly misdiagnosed tumour in the thorax.
- Source :
-
Histopathology [Histopathology] 2016 Nov; Vol. 69 (5), pp. 752-761. Date of Electronic Publication: 2016 Jul 08. - Publication Year :
- 2016
-
Abstract
- Aims: Follicular dendritic cell sarcoma is a rare tumour reported to occur occasionally in association with the hyaline-vascular type of Castleman's disease (HVCD). Most cases arise in lymph nodes, although extranodal presentation is described.<br />Methods and Results: Clinical, radiological and histological characteristics, including diagnosis on pre-resection material, were assessed in seven intrathoracic cases from five males and two females with a median age of 38 years. Clinical symptoms were related to mass location, six cases presenting within central and/or posterior mediastinal compartments and one within the lungs. Positron emission tomography-computed tomography demonstrated marked fluoro-deoxy-glucose avidity and the prominent vessels traversing the lesions. Four of six cases (67%) were misdiagnosed initially. HVCD was present in three cases. Two cases with high mitotic rates recurred after resection. All were positive for at least one of the follicular dendritic cell markers (CD21, CD35 and CD23). Six of seven cases (86%) show cyclin D1 expression ranging from 5% to 90%.<br />Conclusions: Follicular dendritic cell sarcoma is often misdiagnosed on biopsy and pathologists need to be aware of the tumour to request the relevant immunohistochemistry, especially in masses presenting in the central/posterior mediastinum with high vascularity and standardized uptake values. Background HVCD appears more common than previously thought.<br /> (© 2016 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Biomarkers, Tumor analysis
Dendritic Cell Sarcoma, Follicular diagnosis
Female
Humans
Immunohistochemistry
Lung Neoplasms diagnosis
Male
Mediastinal Neoplasms diagnosis
Middle Aged
Thorax
Young Adult
Dendritic Cell Sarcoma, Follicular pathology
Lung Neoplasms pathology
Mediastinal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2559
- Volume :
- 69
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 27206572
- Full Text :
- https://doi.org/10.1111/his.12998