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Transient spectra study on photo-dynamics of curcumin.
- Source :
-
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2016 Sep 05; Vol. 166, pp. 38-43. Date of Electronic Publication: 2016 May 06. - Publication Year :
- 2016
-
Abstract
- A novel mechanism of DNA damage induced by photosensitized curcumin (Cur) was explored using laser flash photolysis, pulse radiolysis and gel electrophoresis. Cur neutral radical (Cur) was confirmed as an identical product in photo-sensitization of Cur by laser flash photolysis and pulse radiolysis. A series of reaction rate constants between Cur and nucleic acid bases/nucleotides were determined by pulse radiolysis. Gel electrophoresis was carried out to investigate damage induced by photosensitized Cur to biologically active DNA. The results indicate that the damage to DNA may be caused by Cur produced from the photosensitization of Cur.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Antineoplastic Agents chemistry
Curcumin chemistry
Free Radicals chemistry
Humans
Neoplasms drug therapy
Photolysis
Photosensitizing Agents chemistry
Pulse Radiolysis
Antineoplastic Agents pharmacology
Curcumin pharmacology
DNA Damage drug effects
Free Radicals pharmacology
Photosensitizing Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3557
- Volume :
- 166
- Database :
- MEDLINE
- Journal :
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
- Publication Type :
- Academic Journal
- Accession number :
- 27203233
- Full Text :
- https://doi.org/10.1016/j.saa.2016.04.051