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Population-Attributable Risk of Risk Factors for Recurrent Wheezing in Moderate Preterm Infants During the First Year of Life.

Authors :
Blanken MO
Korsten K
Achten NB
Tamminga S
Nibbelke EE
Sanders EA
Smit HA
Groenwold RH
Bont L
Source :
Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2016 Jul; Vol. 30 (4), pp. 376-85. Date of Electronic Publication: 2016 May 16.
Publication Year :
2016

Abstract

Background: Recurrent wheezing in young infants has a high prevalence, influences quality of life, and generates substantial health care costs. We previously showed that respiratory syncytial virus infection is an important mechanism of recurrent wheezing in moderate preterm infants. We aimed to provide population-attributable risks (PAR) of risk factors for recurrent wheezing during the first year of life in otherwise healthy moderate preterm infants.<br />Methods: RISK is a multicentre prospective birth cohort study of 4424 moderate preterm infants born at 32-35 weeks gestation. We estimated PAR of risk factors for recurrent wheezing, which was defined as three or more parent-reported wheezing episodes during the first year of life.<br />Results: We evaluated 3952 (89%) children at 1 year of age, of whom 705 infants (18%) developed recurrent wheezing. Fourteen variables were independently associated with recurrent wheezing. Hospitalisation for respiratory syncytial virus bronchiolitis had a strong relationship with recurrent wheezing (RR 2.6; 95% confidence interval, CI, 2.2, 3.1), but a relative modest PAR (8%; 95% CI 6, 11%) which can be explained by a low prevalence (13%). Day-care attendance showed a strong relationship with recurrent wheezing (RR 1.9; 95% CI 1.7, 2.2) and the highest PAR (32%; 95% CI 23, 37%) due to a high prevalence (67%). The combined adjusted PAR for the 14 risk factors associated with recurrent wheezing was 49% (95% CI 46, 52%).<br />Conclusions: In moderate preterm infants, day-care attendance has the largest PAR for recurrent wheezing. Trial evidence is needed to determine the potential benefit of delayed day-care attendance in this population.<br /> (© 2016 John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1365-3016
Volume :
30
Issue :
4
Database :
MEDLINE
Journal :
Paediatric and perinatal epidemiology
Publication Type :
Academic Journal
Accession number :
27199198
Full Text :
https://doi.org/10.1111/ppe.12295