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Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.

Authors :
Cannioto R
LaMonte MJ
Risch HA
Hong CC
Sucheston-Campbell LE
Eng KH
Brian Szender J
Chang-Claude J
Schmalfeldt B
Klapdor R
Gower E
Minlikeeva AN
Zirpoli GR
Bandera EV
Berchuck A
Cramer D
Doherty JA
Edwards RP
Fridley BL
Goode EL
Goodman MT
Hogdall E
Hosono S
Jensen A
Jordan S
Kjaer SK
Matsuo K
Ness RB
Olsen CM
Olson SH
Leigh Pearce C
Pike MC
Anne Rossing M
Szamreta EA
Thompson PJ
Tseng CC
Vierkant RA
Webb PM
Wentzensen N
Wicklund KG
Winham SJ
Wu AH
Modugno F
Schildkraut JM
Terry KL
Kelemen LE
Moysich KB
Source :
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2016 Jul; Vol. 25 (7), pp. 1114-24. Date of Electronic Publication: 2016 May 06.
Publication Year :
2016

Abstract

Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk.<br />Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index.<br />Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype.<br />Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes.<br />Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease. Cancer Epidemiol Biomarkers Prev; 25(7); 1114-24. ©2016 AACR.<br /> (©2016 American Association for Cancer Research.)

Details

Language :
English
ISSN :
1538-7755
Volume :
25
Issue :
7
Database :
MEDLINE
Journal :
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Publication Type :
Academic Journal
Accession number :
27197285
Full Text :
https://doi.org/10.1158/1055-9965.EPI-15-1330