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Oral Hygiene and Risk of Nasopharyngeal Carcinoma-A Population-Based Case-Control Study in China.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2016 Aug; Vol. 25 (8), pp. 1201-7. Date of Electronic Publication: 2016 May 19. - Publication Year :
- 2016
-
Abstract
- Background: The association between oral health and risk of nasopharyngeal carcinoma (NPC) is largely unknown. Further understanding could shed light on potential pathogenic mechanisms and preventive measures.<br />Methods: We conducted a population-based case-control study in southern China between 2010 and 2014. We enrolled 2,528 incident NPC cases, aged 20-74 years, and 2,596 controls, randomly selected from the total population registers, with frequency matching to the 5-year age and sex distribution of the cases by geographic region. We interviewed subjects using a structured questionnaire inquiring about oral health indicators and potential confounding factors. We used unconditional logistic regression to estimate multivariate-adjusted ORs with 95% confidence intervals (CI).<br />Results: A higher number of filled teeth was associated with an elevated risk of NPC. Individuals with 1 to 3 and more than 3 teeth filled versus none had adjusted ORs of 1.25 (95% CI, 1.06-1.49) and 1.55 (95% CI, 1.13-2.12), respectively (Ptrend = 0.002). Conversely, the adjusted OR for those who brushed teeth twice or more per day versus once or less per day was 0.62 (95% CI, 0.55-0.70). We detected a borderline significant positive association with earlier age at first adult tooth loss.<br />Conclusion: Our study suggested a positive association between some indicators of poor oral health and risk of NPC. Further studies are needed to confirm whether the findings are causal and, if so, to further explain the underlying mechanisms.<br />Impact: Improvement of oral hygiene might contribute to reducing NPC risk. Cancer Epidemiol Biomarkers Prev; 25(8); 1201-7. ©2016 AACR.<br /> (©2016 American Association for Cancer Research.)
- Subjects :
- Adult
Aged
Case-Control Studies
China epidemiology
Dental Caries epidemiology
Female
Humans
Logistic Models
Male
Middle Aged
Nasopharyngeal Carcinoma
Odds Ratio
Oral Health statistics & numerical data
Population Surveillance
Pregnancy
Risk Factors
Surveys and Questionnaires
Tooth Loss epidemiology
Young Adult
Carcinoma etiology
Nasopharyngeal Neoplasms etiology
Oral Hygiene statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7755
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27197279
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-16-0149