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Low serum vitamin D is associated with higher cortical porosity in elderly men.
- Source :
-
Journal of internal medicine [J Intern Med] 2016 Nov; Vol. 280 (5), pp. 496-508. Date of Electronic Publication: 2016 May 15. - Publication Year :
- 2016
-
Abstract
- Background: Bone loss at peripheral sites in the elderly is mainly cortical and involves increased cortical porosity. However, an association between bone loss at these sites and 25-hydroxyvitamin D has not been reported.<br />Objective: To investigate the association between serum levels of 25-hydroxyvitamin D, bone microstructure and areal bone mineral density (BMD) in elderly men.<br />Methods: A population-based cohort of 444 elderly men (mean ± SD age 80.2 ± 3.5 years) was investigated. Bone microstructure was measured by high-resolution peripheral quantitative computed tomography, areal BMD by dual-energy X-ray absorptiometry and serum 25-hydroxyvitamin D and parathyroid hormone levels by immunoassay.<br />Results: Mean cortical porosity at the distal tibia was 14.7% higher (12.5 ± 4.3% vs. 10.9 ± 4.1%, P < 0.05) whilst cortical volumetric BMD, area, trabecular bone volume fraction and femoral neck areal BMD were lower in men in the lowest quartile of vitamin D levels compared to the highest. In men with vitamin D deficiency (<25 nmol L <superscript>-1</superscript> ) or insufficiency [25-49 nmol L <superscript>-1</superscript> , in combination with an elevated serum level of parathyroid hormone (>6.8 pmol L <superscript>-1</superscript> )], cortical porosity was 17.2% higher than in vitamin D-sufficient men (P < 0.01). A linear regression model including age, weight, height, daily calcium intake, physical activity, smoking vitamin D supplementation and parathyroid hormone showed that 25-hydroxyvitamin D independently predicted cortical porosity (standardized β = -0.110, R <superscript>2</superscript> = 1.1%, P = 0.024), area (β = 0.123, R <superscript>2</superscript> = 1.4%, P = 0.007) and cortical volumetric BMD (β = 0.125, R <superscript>2</superscript> = 1.4%, P = 0.007) of the tibia as well as areal BMD of the femoral neck (β = 0.102, R <superscript>2</superscript> = 0.9%, P = 0.04).<br />Conclusion: Serum vitamin D is associated with cortical porosity, area and density, indicating that bone fragility as a result of low vitamin D could be due to changes in cortical bone microstructure and geometry.<br /> (© 2016 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.)
- Subjects :
- Absorptiometry, Photon
Aged
Aged, 80 and over
Cortical Bone diagnostic imaging
Follow-Up Studies
Humans
Linear Models
Male
Parathyroid Hormone blood
Porosity
Prospective Studies
Tibia pathology
Vitamin D blood
Vitamin D Deficiency pathology
Bone Density
Cortical Bone pathology
Vitamin D analogs & derivatives
Vitamin D Deficiency physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2796
- Volume :
- 280
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27196563
- Full Text :
- https://doi.org/10.1111/joim.12514