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Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling.
- Source :
-
Stem cells international [Stem Cells Int] 2016; Vol. 2016, pp. 8419104. Date of Electronic Publication: 2016 Apr 13. - Publication Year :
- 2016
-
Abstract
- Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.
Details
- Language :
- English
- ISSN :
- 1687-966X
- Volume :
- 2016
- Database :
- MEDLINE
- Journal :
- Stem cells international
- Publication Type :
- Academic Journal
- Accession number :
- 27190524
- Full Text :
- https://doi.org/10.1155/2016/8419104