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KIT polymorphisms were associated with the risk for head and neck squamous carcinoma in Chinese population.
- Source :
-
Molecular carcinogenesis [Mol Carcinog] 2017 Jan; Vol. 56 (1), pp. 232-237. Date of Electronic Publication: 2016 May 17. - Publication Year :
- 2017
-
Abstract
- KITLG/KIT pathway plays a vital role in multiple types of human cancer including head and neck squamous cell carcinoma (HNSCC). Genetic variations in KITLG and KIT may affect the expression or function of these genes, thereby modifying cancer risk. In this study, we evaluated the association of KITLG and KIT polymorphisms with HNSCC risk among Chinese population. Twenty-two tagging SNPs in KITLG and KIT genes were genotyped in a case-control study with 576 HNSCC patients and 1552 healthy controls. Logistic regression analyses revealed that an upstream SNP rs6554198 [additive model: adjusted odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.74-0.97, P = 0.019] and two intron SNPs rs2237025 (additive model: adjusted OR = 0.82, 95%CI = 0.70-0.95, P = 0.007), and rs17084687 (additive model: adjusted OR = 0.85, 95%CI = 0.73-0.99, P = 0.042) of KIT were significantly associated with the decreased risk of HNSCC. Combined analysis of the three SNPs showed that subjects carrying the protective alleles had decreased risk of HNSCC in a dose-response manner (P <subscript>trend</subscript> = 0.001). Furthermore, interaction analyses revealed a significant multiplicative interaction between rs17084687 and drinking on HNSCC risk (P = 0.012). Luciferase activity assay indicated that the allele A of potentially functional rs6554198 led to significantly lower transcription activity of KIT compared to the risk allele G. Summarily, our findings suggested that SNPs in KIT gene may play a role in genetic susceptibility to HNSCC, which may improve our understanding of the pathogenic mechanisms of this disease. © 2016 Wiley Periodicals, Inc.<br /> (© 2016 Wiley Periodicals, Inc.)
- Subjects :
- Asian People genetics
Carcinoma, Squamous Cell epidemiology
Case-Control Studies
China epidemiology
Female
Genetic Predisposition to Disease
Genotype
Head and Neck Neoplasms epidemiology
Humans
Male
Middle Aged
Risk Factors
Squamous Cell Carcinoma of Head and Neck
Stem Cell Factor genetics
Carcinoma, Squamous Cell genetics
Head and Neck Neoplasms genetics
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-kit genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-2744
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 27186940
- Full Text :
- https://doi.org/10.1002/mc.22487