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The IL4-VNTR P1 Allele, IL4-VNTR P2P2 Genotype, and IL4-VNTR_IL6-174CG P2P1-GG Genotype Are Associated with an Increased Risk of Brucellosis.
- Source :
-
Japanese journal of infectious diseases [Jpn J Infect Dis] 2017 Jan 24; Vol. 70 (1), pp. 61-64. Date of Electronic Publication: 2016 May 09. - Publication Year :
- 2017
-
Abstract
- In this study, associations between IL-4, IL-6, and macrophage migration inhibitory factor (MIF) polymorphisms and susceptibility to brucellosis were investigated. Consecutive adult patients with no known treatment against brucellosis and who did not have any other autoimmune and/or chronic disorders, were included in this study (n = 120, Group I). Age and sex-matched controls who had no other autoimmune and/or chronic disorders were also included (n = 120, healthy volunteers, Group II). The IL4_P2P2 genotype, IL4_P1 allele, and IL4_variable number of tandem repeats (VNTR)_IL6-174CG compound genotype were found to be more frequent in the patient group than in control subjects. There were significant differences between the patients and controls with respect to the frequencies of the IL4_P2P2 genotype (77.5% versus 87.5%; p = 0.001; OR, 0.36; 95% confidence interval [CI], 0.21-0.62) and the IL4_P1 allele (12.1% versus 6.7%; p = 0.030; OR, 0.92; CI, 1.02-3.64). The IL4-VNTR_IL6-174CG compound genotype was also present at a significantly higher frequency in the patient group than in control subjects (11.7% versus 4.2%; p = 0.027, OR, 3.04; CI, 1.06-8.68). No statistically significant differences in the frequencies of the IL-6-174, MIF-173, IL-4_P1P1, and IL4_P2P1 genotypes were observed between patients and control subjects. The IL4_VNTR P1 allele, P2P2 genotypes, and IL4-VNTR_IL6-174CG P2P1-GG genotypes are common in southern Turkey, and carriers of these polymorphisms are susceptible to brucellosis.
- Subjects :
- Adolescent
Adult
Aged
Female
Gene Frequency
Humans
Intramolecular Oxidoreductases genetics
Macrophage Migration-Inhibitory Factors genetics
Male
Middle Aged
Risk Assessment
Turkey
Young Adult
Brucellosis genetics
Genetic Predisposition to Disease
Genotype
Interleukin-4 genetics
Interleukin-6 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1884-2836
- Volume :
- 70
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Japanese journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 27169944
- Full Text :
- https://doi.org/10.7883/yoken.JJID.2015.550