Back to Search
Start Over
Feasibility and Safety of Transhiatal Approach and D2 Total Gastrectomy after Neoadjuvant Chemotherapy for Adenocarcinoma of the Esophago-Gastric Junction: A Subset Analysis of the COMPASS Trial.
- Source :
-
Digestive surgery [Dig Surg] 2016; Vol. 33 (5), pp. 424-30. Date of Electronic Publication: 2016 May 11. - Publication Year :
- 2016
-
Abstract
- Background: It was unclear whether the transhiatal approach and D2 total gastrectomy after neoadjuvant chemotherapy (NAC) for adenocarcinoma of the esophago-gastric (AEG) junction are as feasible and safe as D2 gastrectomy following NAC.<br />Patients and Methods: We clarified the short-term surgical results in AEG and non-AEG patients in a subset analysis of the COMPASS trial.<br />Results: Eighty-three patients, 24 with AEG and 59 with non-AEG, were registered in the study. Among 24 patients with AEG, 5 were classified to have Siewert type I, 11 to have type II and 8 to have type III. The tumor progression, completion of NAC, and clinical and pathological responses were similar between the groups. Twenty-four AEG and 51 non-AEG patients proceeded to surgery. The extent of dissection (D1/D2) was 3/21 in the AEG and 3/48 in the non-AEG patients. The R0 resection rate was 69% in the non-AEG and 88% in the AEG patients. Neither grade 3b/4 morbidity nor surgical mortality was observed in either group.<br />Conclusions: The transhiatal approach and D2 total gastrectomy after NAC seem to be as safe and feasible as D2 gastrectomy for non-AEG cancer.<br /> (© 2016 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Cisplatin administration & dosage
Dissection
Drug Combinations
Feasibility Studies
Female
Gastrectomy adverse effects
Humans
Male
Margins of Excision
Middle Aged
Neoadjuvant Therapy
Neoplasm, Residual
Oxonic Acid administration & dosage
Paclitaxel administration & dosage
Tegafur administration & dosage
Adenocarcinoma drug therapy
Adenocarcinoma surgery
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Esophagogastric Junction surgery
Gastrectomy methods
Stomach Neoplasms drug therapy
Stomach Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9883
- Volume :
- 33
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Digestive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 27164988
- Full Text :
- https://doi.org/10.1159/000444457