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Data on the lipoprotein (a), coronary atherosclerotic burden and vulnerable plaque phenotype in angiographic obstructive coronary artery disease.

Authors :
Niccoli G
Chin D
Scalone G
Panebianco M
Abbolito S
Cosentino N
Jacoangeli F
Refaat H
Gallo G
Salerno G
Volpe M
Crea F
De Biase L
Source :
Data in brief [Data Brief] 2016 Apr 13; Vol. 7, pp. 1409-12. Date of Electronic Publication: 2016 Apr 13 (Print Publication: 2016).
Publication Year :
2016

Abstract

Lipoprotein Lp(a) represents an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden and lipid rich plaques prone to rupture in patients with acute coronary syndrome (ACS) still remains unknown. These data aim to investigate the association among serum Lipoprotein(a) (Lpa) levels, coronary atherosclerotic burden and features of culprit plaque in patients with ACS and obstructive CAD. For his reason, a total of 500 ACS patients were enrolled for the angiographic cohort and 51 ACS patients were enrolled for the optical coherence tomography (OCT) cohort. Angiographic CAD severity was assessed by Sullivan score and by Bogaty score including stenosis score and extent index, whereas OCT plaque features were evaluated at the site of the minimal lumen area and along the culprit segment. In the angiographic cohort, Lp(a) was a weak independent predictor of Sullivan score (p<0.0001), stenosis score (p<0.0001) and extent index (p<0.0001). In the OCT cohort, patients with higher Lp(a) levels (>30 md/dl) compared to patients with lower Lp(a) levels (<30 md/dl) exhibited a higher prevalence of lipidic plaque at the site of the culprit stenosis (P=0.02), a wider lipid arc (p=0.003) and a higher prevalence of thin-cap fibroatheroma (p=0.004).

Details

Language :
English
ISSN :
2352-3409
Volume :
7
Database :
MEDLINE
Journal :
Data in brief
Publication Type :
Academic Journal
Accession number :
27158659
Full Text :
https://doi.org/10.1016/j.dib.2016.04.017