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Osteoclast function and bone-resorbing activity: An overview.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 Jul 29; Vol. 476 (3), pp. 115-20. Date of Electronic Publication: 2016 May 05. - Publication Year :
- 2016
-
Abstract
- Bone resorption is an important cellular function in skeletal development and remodeling of the adult skeleton. Most of the pathological bone disease conditions like osteoporosis reflect increased osteoclast activity; hence, increased bone resorption. Researchers have unraveled most of the intracellular mechanisms responsible for osteoclast bone-resorbing activity in last few decades. Therefore, understanding the fundamentals of osteoclast-induced bone resorption and the cytokines and other substances that modulate the osteoclast activity unequivocally provide insights into the development of drugs to ameliorate pathological bone diseases with enhanced bone resorption. The aim of this review is to examine the literature on osteoclast function and bone-resorbing activity.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 476
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 27157135
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.05.019