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Audiological profile of patients treated for childhood cancer.
- Source :
-
Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2016 Nov - Dec; Vol. 82 (6), pp. 623-629. Date of Electronic Publication: 2016 Apr 13. - Publication Year :
- 2016
-
Abstract
- Objective: To characterize the hearing loss after cancer treatment, according to the type of treatment, with identification of predictive factors.<br />Methods: Two hundred patients who had cancer in childhood were prospectively evaluated. The mean age at diagnosis was 6 years, and at the audiometric assessment, 21 years. The treatment of the participants included chemotherapy without using platinum derivatives or head and neck radiotherapy in 51 patients; chemotherapy using cisplatin without radiotherapy in 64 patients; head and neck radiotherapy without cisplatin in 75 patients; and a combined treatment of head and neck radiotherapy and chemotherapy with cisplatin in ten patients. Patients underwent audiological assessment, including pure tone audiometry, speech audiometry, and immittancemetry.<br />Results: The treatment involving chemotherapy with cisplatin caused 41.9% and 47.3% hearing loss in the right and left ear, respectively, with a 11.7-fold higher risk of hearing loss in the right ear and 17.6-fold higher in the left ear versus patients not treated with cisplatin (p<0.001 and p<0.001, respectively). Children whose cancer diagnosis occurred after the age of 6 have shown an increased risk of hearing loss vs. children whose diagnosis occurred under 6 years of age (p=0.02).<br />Conclusion: The auditory feature found after the cancer treatment was a symmetrical bilateral sensorineural hearing loss. Chemotherapy with cisplatin proved to be a risk factor, while head and neck radiotherapy was not critical for the occurrence of hearing loss.<br /> (Copyright © 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)
- Subjects :
- Age Factors
Audiometry, Pure-Tone
Child
Child, Preschool
Combined Modality Therapy
Female
Hearing Loss, Bilateral diagnosis
Hearing Loss, Sensorineural diagnosis
Humans
Male
Neoplasms drug therapy
Neoplasms radiotherapy
Prospective Studies
Radiotherapy adverse effects
Risk Factors
Young Adult
Antineoplastic Agents adverse effects
Cisplatin adverse effects
Hearing Loss, Bilateral etiology
Hearing Loss, Sensorineural etiology
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1808-8686
- Volume :
- 82
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Brazilian journal of otorhinolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 27156673
- Full Text :
- https://doi.org/10.1016/j.bjorl.2015.11.021