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Pancreatic Lipase Immunoreactivity in Serum of Dogs with Diabetic Ketoacidosis.
- Source :
-
Journal of veterinary internal medicine [J Vet Intern Med] 2016 Jul; Vol. 30 (4), pp. 958-63. Date of Electronic Publication: 2016 May 07. - Publication Year :
- 2016
-
Abstract
- Background: Diabetic ketoacidosis (DKA) is a relatively common endocrine disorder in dogs and is routinely associated with concurrent pancreatic injury.<br />Objectives: The aims of this study were to determine the prevalence of pancreatic injury in dogs with DKA based on measurement of pancreatic lipase immunoreactivity in serum (PLI); compare demographic, clinicopathologic, and ultrasonographic findings in dogs with and without evidence of concurrent pancreatic injury; determine the impact of pancreatic injury on duration of hospitalization and short-term outcome.<br />Animals: One hundred and nineteen dogs with DKA with or without concurrent pancreatic injury.<br />Methods: Retrospective study. Dogs with DKA were divided into three groups on the basis of PLI results: positive for pancreatic injury (PLIpos ), negative for pancreatic injury (PLIneg ), and not tested (PLIna ). Demographics, clinicopathologic test results, findings on abdominal ultrasonography (AUS), duration of hospitalization, and short-term outcome were compared between the three groups.<br />Results: Based on serum PLI activity, 45 dogs (73%) with DKA had evidence of concurrent pancreatic injury. Median total carbon dioxide was significantly lower in the PLIpos dogs compared to the PLIneg dogs. There was fair agreement (κ = 0.26) between serum PLI activity and AUS. Evidence of pancreatic injury was not associated with significantly longer periods of hospitalization (PLIpos median 6 days, range 4-7 days, PLIneg median 4 days, range 3-6 days) and did not influence short-term outcome (PLIpos failure to survive to discharge 11/45, 24%, PLIneg failure to survive to discharge 2/17, 12%).<br />Clinical Importance: Concurrent pancreatic injury is common in dogs with DKA, but did not affect prognosis in this population of dogs.<br /> (Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
- Subjects :
- Animals
Diabetic Ketoacidosis blood
Dogs
Exocrine Pancreatic Insufficiency blood
Exocrine Pancreatic Insufficiency pathology
Exocrine Pancreatic Insufficiency veterinary
Lipase metabolism
Pancreas diagnostic imaging
Pancreas pathology
Prognosis
Retrospective Studies
Ultrasonography
Diabetic Ketoacidosis veterinary
Dog Diseases blood
Lipase blood
Pancreas enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1939-1676
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of veterinary internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27155726
- Full Text :
- https://doi.org/10.1111/jvim.13955