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Menstrual patterns, fertility and main pregnancy outcomes after allogeneic haematopoietic stem cell transplantation.
- Source :
-
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology [J Obstet Gynaecol] 2016 Aug; Vol. 36 (6), pp. 783-788. Date of Electronic Publication: 2016 May 06. - Publication Year :
- 2016
-
Abstract
- Two-hundred and sixty-nine females aged ≤42 and undergoing an allogeneic stem cell transplant were retrospectively studied to assess the effect of age, conditioning regimen and chronic graft-versus-host disease (cGVHD) on resumption of stable menstrual cyclicity. Overall, a stable menstrual cyclicity was observed in 22% of cases. The cumulative probability of menses resumption was significantly age and conditioning regimen related. A statistically significant inverse correlation between cGVHD severity and menses resumption was observed only in univariate analysis. In patients with residual ovarian function, infertility was found in 43% and early menopause in 45%. An increased incidence of prematurity and low birth weight (LBW) was observed among the single spontaneous pregnancies. Follicle-stimulating hormone (FSH) and 17 beta-oestradiol levels were found to be inadequate to detect both early signs of menses resumption and menstrual stability. Our study confirms the crucial role of full dose total body irradiation (TBI) and age on menses recovery and fertility after haematopoietic stem cell transplantation (HSCT). The impact of severe cGVHD remains unclear.
- Subjects :
- Adult
Age Factors
Estradiol blood
Female
Follicle Stimulating Hormone blood
Graft vs Host Disease etiology
Hematopoietic Stem Cell Transplantation methods
Humans
Infertility etiology
Menstruation Disturbances blood
Pregnancy
Pregnancy Outcome
Retrospective Studies
Transplantation Conditioning methods
Fertility
Hematopoietic Stem Cell Transplantation adverse effects
Menstrual Cycle
Menstruation Disturbances etiology
Transplantation Conditioning adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1364-6893
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
- Publication Type :
- Academic Journal
- Accession number :
- 27153290
- Full Text :
- https://doi.org/10.3109/01443615.2016.1154508