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[Role of GAGA Factor in Drosophila Primordial Germ Cell Migration and Gonad Development].
- Source :
-
Ontogenez [Ontogenez] 2016 Jan-Feb; Vol. 47 (1), pp. 40-8. - Publication Year :
- 2016
-
Abstract
- The GAGA protein of drosophila is a factor involved in epigenetic transcription regulation of a large gene group controlling developmental processes. In this paper, the role of GAGA factor in germ cell migration is demonstrated as well as its effect on the gonad development in drosophila embryogenesis. Mutations in the Trl gene, encoding GAGA factor, prematurely induces the active migration program and relocation of the primordial cells inward the embryo before the beginning of gastrulation. The germ cells that prematurely separated from the main group migrate ectopically, lose orientation, and stay out of gonad development. Expression pattern of the Trl gene suggests its activity in epithelial cells of the embryonic blastoderm, part of which contact primordial cells. Thus, GAGA factor influences migration of these cells in an indirect manner via their somatic environment.
- Subjects :
- Animals
DNA-Binding Proteins genetics
Drosophila Proteins genetics
Drosophila melanogaster
Embryo, Nonmammalian cytology
Germ Cells cytology
Gonads cytology
Humans
Male
Transcription Factors genetics
Cell Movement physiology
DNA-Binding Proteins metabolism
Drosophila Proteins metabolism
Embryo, Nonmammalian embryology
Germ Cells metabolism
Gonads embryology
Transcription Factors metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0475-1450
- Volume :
- 47
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Ontogenez
- Publication Type :
- Academic Journal
- Accession number :
- 27149747