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Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress.
- Source :
-
Annual review of nutrition [Annu Rev Nutr] 2016 Jul 17; Vol. 36, pp. 241-73. Date of Electronic Publication: 2016 May 04. - Publication Year :
- 2016
-
Abstract
- Dietary advice is the cornerstone in first-line treatment of metabolic diseases. Nutritional interventions directed at these clinical conditions mainly aim to (a) improve insulin resistance by reducing energy-dense macronutrient intake to obtain weight loss and (b) reduce fluctuations in insulin secretion through avoidance of rapidly absorbable carbohydrates. However, even in the majority of motivated patients selected for clinical trials, massive efforts using this approach have failed to achieve lasting efficacy. Less attention has been given to the role of micronutrients in metabolic diseases. Here, we review the evidence that highlights (a) the importance of iron in pancreatic beta-cell function and dysfunction in diabetes and (b) the integrative pathophysiological effects of tissue iron levels in the interactions among the beta cell, gut microbiome, hypothalamus, innate and adaptive immune systems, and insulin-sensitive tissues. We propose that clinical trials are warranted to clarify the impact of dietary or pharmacological iron reduction on the development of metabolic disorders.
- Subjects :
- Adaptive Immunity
Animals
Apoptosis
Diabetes Mellitus etiology
Diabetes Mellitus immunology
Diabetes Mellitus metabolism
Dietary Supplements adverse effects
Gastrointestinal Microbiome immunology
Homeostasis
Humans
Hypothalamus immunology
Hypothalamus metabolism
Immunity, Innate
Insulin Secretion
Insulin-Secreting Cells immunology
Insulin-Secreting Cells pathology
Iron Overload immunology
Iron Overload metabolism
Iron Overload pathology
Iron Overload physiopathology
Iron, Dietary adverse effects
Iron, Dietary metabolism
Reactive Oxygen Species agonists
Reactive Oxygen Species metabolism
Diabetes Mellitus prevention & control
Evidence-Based Medicine
Insulin metabolism
Insulin Resistance
Insulin-Secreting Cells metabolism
Iron, Dietary therapeutic use
Oxidative Stress
Subjects
Details
- Language :
- English
- ISSN :
- 1545-4312
- Volume :
- 36
- Database :
- MEDLINE
- Journal :
- Annual review of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 27146016
- Full Text :
- https://doi.org/10.1146/annurev-nutr-071715-050939