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Safety of insulin analogues as compared with human insulin in pregnancy.
- Source :
-
Expert opinion on drug safety [Expert Opin Drug Saf] 2016 Jul; Vol. 15 (7), pp. 963-73. Date of Electronic Publication: 2016 May 17. - Publication Year :
- 2016
-
Abstract
- Introduction: Diabetes during pregnancy may lead to maternal, fetal and neonatal complications. In order to limit unwarranted outcomes, strict glycemic control is essential. In the past, human insulin was the only insulin formulation administered in pregnancy. However, insulin analogues have also been used for this indication in recent years.<br />Areas Covered: This article reviews the published data regarding the safety of insulin analogue use during pregnancy. We present the qualities, advantages and pitfalls of insulin analogue use in pregnancy compared with human insulin. Insulins lispro, aspart and detemir are safe in pregnant women with type 1 diabetes. Correspondingly, they were reclassified for the treatment of pregnant women with diabetes from category C to category B. For insulin glargine use in pregnancy, most studies are small and retrospective. Yet, no major safety concerns were reported. Insulin glulisine and degludec have not been studied in pregnancy.<br />Expert Opinion: Insulin analogues are viable therapeutic options for diabetes in pregnancy, specifically lispro, aspart and detemir. Though data in limited, their safety and efficacy are comparable with human insulin. Remarkably, the analogues are superior to human insulin regarding hypoglycaemia risk. More data, specifically for their use in pregnancies complicated by gestational diabetes or type 2 diabetes, is needed.
- Subjects :
- Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 1 drug therapy
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 drug therapy
Female
Humans
Hypoglycemia chemically induced
Hypoglycemic Agents adverse effects
Hypoglycemic Agents classification
Infant, Newborn
Insulin, Regular, Human administration & dosage
Insulin, Regular, Human adverse effects
Insulin, Regular, Human classification
Insulins adverse effects
Insulins classification
Pregnancy
Diabetes, Gestational drug therapy
Hypoglycemic Agents administration & dosage
Insulins administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1744-764X
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Expert opinion on drug safety
- Publication Type :
- Academic Journal
- Accession number :
- 27145344
- Full Text :
- https://doi.org/10.1080/14740338.2016.1182153