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Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells.
- Source :
-
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2016; Vol. 31 (sup1), pp. 119-125. Date of Electronic Publication: 2016 May 03. - Publication Year :
- 2016
-
Abstract
- Context: Proton Pump Inhibitors (PPIs) reduce tumor acidity and therefore resistance of tumors to drugs. Carbonic Anhydrase IX (CA IX) inhibitors have proven to be effective against tumors, while tumor acidity might impair their full effectiveness.<br />Objective: To analyze the effect of PPI/CA IX inhibitors combined treatment against human melanoma cells.<br />Methods: The combination of Lansoprazole (LAN) and CA IX inhibitors (FC9-399A and S4) has been investigated in terms of cell proliferation inhibition and cell death in human melanoma cells.<br />Results: The combination of these inhibitors was more effective than the single treatments in both inhibiting cell proliferation and in inducing cell death in human melanoma cells.<br />Discussion: These results represent the first successful attempt in combining two different proton exchanger inhibitors.<br />Conclusion: This is the first evidence on the effectiveness of a new approach against tumors based on the combination of PPI and CA IX inhibitors, thus providing an alternative strategy against tumors.
- Subjects :
- Antigens, Neoplasm metabolism
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Carbonic Anhydrase IX metabolism
Carbonic Anhydrase Inhibitors chemical synthesis
Carbonic Anhydrase Inhibitors chemistry
Cell Death drug effects
Cell Line, Tumor
Cell Proliferation drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Drug Synergism
Humans
Lansoprazole chemical synthesis
Lansoprazole chemistry
Molecular Structure
Structure-Activity Relationship
Antineoplastic Agents pharmacology
Carbonic Anhydrase IX antagonists & inhibitors
Carbonic Anhydrase Inhibitors pharmacology
Lansoprazole pharmacology
Melanoma drug therapy
Melanoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1475-6374
- Volume :
- 31
- Issue :
- sup1
- Database :
- MEDLINE
- Journal :
- Journal of enzyme inhibition and medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27142956
- Full Text :
- https://doi.org/10.1080/14756366.2016.1177525