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Incidence rate of falls and its risk factors in patients with rheumatoid arthritis compared to controls: Four years of the TOMORROW study.
- Source :
-
Modern rheumatology [Mod Rheumatol] 2017 Jan; Vol. 27 (1), pp. 8-14. Date of Electronic Publication: 2016 May 04. - Publication Year :
- 2017
-
Abstract
- Objective: Patients with rheumatoid arthritis (RA) have been recognized to experience falls frequently due to functional disabilities. The aim of this study was to prospectively investigate factors influencing falls in patients with RA compared to controls.<br />Methods: We compared the frequency of falls in 208 RA patients and 205 age- and sex-matched volunteers for four years and analyzed risk factors for falls in RA patients using multivariate regression analysis.<br />Results: No significant difference in the incidence rate of falls (/person-year) between patients with RA (median [interquartile range]: 0 [0, 0.5]) and controls (0 [0, 0.5]) was evident during four years. Logistic regression analysis identified age, sex, body mass index, history of falls, and lower limb implant at baseline as significant risk factors for falls. The highest quartile of anti-CCP antibody level (>300.6āU/ml) was the strongest predictor for multiple falls (odds ratio, 2.97; 95% confidence interval, 1.12-7.91, pā=ā0.029) among RA patients.<br />Conclusion: During four years we could not observe the higher incidence rate of falls in RA patients compared to controls in our cohort. Subjects with a higher titer of anti-CCP antibody might be at higher risk of frequent falls among RA patients.
- Subjects :
- Aged
Autoantibodies immunology
Case-Control Studies
Female
Humans
Incidence
Japan epidemiology
Male
Middle Aged
Odds Ratio
Rheumatoid Factor analysis
Risk Factors
Accidental Falls prevention & control
Accidental Falls statistics & numerical data
Arthritis, Rheumatoid diagnosis
Arthritis, Rheumatoid immunology
Arthritis, Rheumatoid physiopathology
Peptides, Cyclic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7609
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Modern rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 27142648
- Full Text :
- https://doi.org/10.1080/14397595.2016.1176625