Maintenance of Epigenetic Information.

Authors :: Almouzni G
Cedar H
Source :: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2016 May 02; Vol. 8 (5). Date of Electronic Publication: 2016 May 02.
Publication Year :: 2016
Abstract: The genome is subject to a diverse array of epigenetic modifications from DNA methylation to histone posttranslational changes. Many of these marks are somatically stable through cell division. This article focuses on our knowledge of the mechanisms governing the inheritance of epigenetic marks, particularly, repressive ones, when the DNA and chromatin template are duplicated in S phase. This involves the action of histone chaperones, nucleosome-remodeling enzymes, histone and DNA methylation binding proteins, and chromatin-modifying enzymes. Last, the timing of DNA replication is discussed, including the question of whether this constitutes an epigenetic mark that facilitates the propagation of epigenetic marks.<br /> (Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.)