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Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages.

Authors :
Unverdorben L
Haufe T
Santoso L
Hofmann S
Jeschke U
Hutter S
Source :
International journal of molecular sciences [Int J Mol Sci] 2016 Apr 28; Vol. 17 (5). Date of Electronic Publication: 2016 Apr 28.
Publication Year :
2016

Abstract

Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.

Details

Language :
English
ISSN :
1422-0067
Volume :
17
Issue :
5
Database :
MEDLINE
Journal :
International journal of molecular sciences
Publication Type :
Academic Journal
Accession number :
27136536
Full Text :
https://doi.org/10.3390/ijms17050644