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Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2016 Apr 28; Vol. 17 (5). Date of Electronic Publication: 2016 Apr 28. - Publication Year :
- 2016
-
Abstract
- Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.
- Subjects :
- Abortion, Spontaneous metabolism
Adult
Case-Control Studies
Demography
Female
Galectin 2 metabolism
Galectin 3 metabolism
Humans
Microscopy, Fluorescence
Placenta pathology
Pregnancy
Pregnancy Trimester, First
Trophoblasts metabolism
Trophoblasts pathology
Abortion, Spontaneous pathology
Galectins metabolism
Placenta metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27136536
- Full Text :
- https://doi.org/10.3390/ijms17050644