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Non-immunosuppressive FTY720-derivative OSU-2S mediates reactive oxygen species-mediated cytotoxicity in canine B-cell lymphoma.
- Source :
-
Veterinary and comparative oncology [Vet Comp Oncol] 2017 Sep; Vol. 15 (3), pp. 1115-1118. Date of Electronic Publication: 2016 May 02. - Publication Year :
- 2017
-
Abstract
- OSU-2S is a FTY720 (Fingolimod) derivative that lacks immunosuppressive properties but exhibits strong anti-tumour activity in several haematological and solid tumour models. We have recently shown OSU-2S to mediate potent cytotoxicity in human mantle cell lymphoma cell lines and primary cells. We report here the pre-clinical activity of OSU-2S in spontaneous B-cell lymphoma of dogs which shares many characteristics of human lymphoma. OSU-2S mediated apoptosis in canine B-cell lines and primary B-cell lymphoma cells obtained from spontaneous lymphoma bearing dogs. OSU-2S induced reactive oxygen species (ROS) in canine lymphoma cells and inhibition of ROS partially rescued OSU-2S-mediated cell death. These studies provide a rational basis for the use of spontaneous lymphoma in pet dogs as a preclinical large animal model for the development of OSU-2S as small molecule for treating people and dogs with lymphoma.<br /> (© 2016 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Apoptosis drug effects
Cells, Cultured
Dogs
Lymphoma, B-Cell drug therapy
Sphingosine therapeutic use
Antineoplastic Agents therapeutic use
Dog Diseases drug therapy
Lymphoma, B-Cell veterinary
Propylene Glycols therapeutic use
Reactive Oxygen Species antagonists & inhibitors
Sphingosine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5829
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary and comparative oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27136276
- Full Text :
- https://doi.org/10.1111/vco.12221