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Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study).
- Source :
-
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia [Nefrologia] 2016 May-Jun; Vol. 36 (3), pp. 255-67. Date of Electronic Publication: 2016 Apr 28. - Publication Year :
- 2016
-
Abstract
- Background and Objectives: The relationship between mineral metabolism disorders, bone fractures and vascular calcifications in kidney transplant recipients has not been established.<br />Method: We performed a cross-sectional study in 727 stable recipients from 28 Spanish transplant clinics. Mineral metabolism parameters, the semi-quantification of vertebral fractures and abdominal aortic calcifications were determined centrally.<br />Results: Vitamin D deficiency (25OHD3<15ng/ml) was more common in female recipients at CKD-T stages I-III (29.6% vs 44.4%; p=0.003). The inverse and significant correlation between 25OHD3 and PTH was gender-specific and women exhibited a steeper slope than men (p=0.01). Vertebral fractures (VFx) with deformity grade ≥2 were observed in 15% of recipients. Factors related to VFx differed by gender; in males, age (OR 1.04; 95% CI 1.01-1.06) and CsA treatment (OR: 3.2; 95% CI: 1.6-6.3); in females, age (OR 1.07; 95% CI: 1.03-1.12) and PTH levels (OR per 100pg/ml increase: 1.27; 95% CI: 1.043-1.542). Abdominal aortic calcifications were common (67.2%) and related to classical risk factors but not to mineral metabolism parameters.<br />Conclusions: Vitamin D deficiency is more common among female kidney transplant recipients at earlier CKD-T stages, and it contributes to secondary hyperparathyroidism. Prevalent vertebral fractures are only related to high serum PTH levels in female recipients.<br /> (Copyright © 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Aged
Albuminuria etiology
Aorta, Abdominal
Aortic Diseases etiology
Calcinosis etiology
Cross-Sectional Studies
Cyclosporine adverse effects
Female
Humans
Hyperparathyroidism, Secondary etiology
Hyperparathyroidism, Secondary metabolism
Immunosuppressive Agents adverse effects
Male
Middle Aged
Parathyroid Hormone blood
Risk Factors
Spinal Fractures etiology
Tacrolimus adverse effects
Vitamin D Deficiency complications
Aortic Diseases metabolism
Calcinosis metabolism
Kidney Transplantation
Minerals metabolism
Postoperative Complications metabolism
Sex Factors
Spinal Fractures metabolism
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1989-2284
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
- Publication Type :
- Academic Journal
- Accession number :
- 27133898
- Full Text :
- https://doi.org/10.1016/j.nefro.2016.03.004