Back to Search
Start Over
Ozone exposure and cardiovascular-related mortality in the Canadian Census Health and Environment Cohort (CANCHEC) by spatial synoptic classification zone.
- Source :
-
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2016 Jul; Vol. 214, pp. 589-599. Date of Electronic Publication: 2016 Apr 29. - Publication Year :
- 2016
-
Abstract
- Our objective is to analyse the association between long term ozone exposure and cardiovascular related mortality while accounting for climate, location, and socioeconomic factors. We assigned subjects with 16 years of follow-up in the Canadian Census Health and Environment Cohort (CanCHEC) to one of seven regions based on spatial synoptic classification (SSC) weather types and examined the interaction of exposure to both fine particulate matter (PM2.5) and ground level ozone and cause of death using survival analysis, while adjusting for socioeconomic characteristics and individual confounders. Correlations between ozone and PM2.5 varied across SSC zones from -0.02 to 0.7. Comparing zones using the most populated SSC zone as a reference, a 10 ppb increase in ozone exposure was associated with increases in hazard ratios (HRs) that ranged from 1.007 (95% CI 0.99, 1.015) to 1.03 (95% CI 1.02, 1.041) for cardiovascular disease, 1.013 (95% CI 0.996, 1.03) to 1.058 (95% CI 1.034, 1.082) for cerebrovascular disease, and 1.02 (95% CI 1.006, 1.034) for ischemic heart disease. HRs remained significant after adjustment for PM2.5. Long term exposure to ozone is related to an increased risk of mortality from cardiovascular and cerebrovascular diseases; the risk varies by location across Canada and is not attenuated by adjustment for PM2.5. This research shows that the SSC can be used to define geographic regions and it demonstrates the importance of accounting for that spatial variability when studying the long term health effects of air pollution.<br /> (Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Air Pollutants analysis
Air Pollution analysis
Canada
Climate
Female
Humans
Male
Ozone analysis
Particulate Matter analysis
Proportional Hazards Models
Socioeconomic Factors
Time Factors
Weather
Air Pollutants toxicity
Cardiovascular Diseases mortality
Censuses
Environmental Exposure
Ozone toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6424
- Volume :
- 214
- Database :
- MEDLINE
- Journal :
- Environmental pollution (Barking, Essex : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 27131819
- Full Text :
- https://doi.org/10.1016/j.envpol.2016.04.067