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Performance of the creatinine and cystatin C-based equations for estimation of GFR in Chinese patients with chronic kidney disease.
- Source :
-
Clinical and experimental nephrology [Clin Exp Nephrol] 2017 Apr; Vol. 21 (2), pp. 236-246. Date of Electronic Publication: 2016 Apr 28. - Publication Year :
- 2017
-
Abstract
- Background: Currently, creatinine- or cystatin C-based glomerular filtration rate (GFR) estimation equation has been recommended to assess GFR in CKD patients. However, it is still obscure whether those equations performed consistently outstandingly in Chinese population.<br />Methods: The equations were validated in a population totaling 632 participants (mean age 61.6 ± 12.3 years). The estimated GFR (eGFR) calculated separately by six equations (C-MDRD, C <subscript>cys</subscript> , C <subscript>scr-cys</subscript> , CKD-EPI <subscript>scr</subscript> , CKD-EPI <subscript>cys</subscript> , and CKD-EPI <subscript>scr-cys</subscript> equations) was compared with the reference GFR (rGFR) measured by the <superscript>99m</superscript> Tc-DTPA renal dynamic imaging method. Participants were divided into age and rGFR specific subgroups.<br />Results: CKD-EPI <subscript>scr-cys</subscript> equation had a larger area under receiver operating characteristic curve (ROC <superscript>AUC</superscript> ) and relative higher sensitivity (79.8 %) and specificity (93 %) to diagnose CKD. CKD-EPI <subscript>scr-cys</subscript> and CKD-EPI <subscript>cys</subscript> equations appeared to be more accurate with higher proportion of eGFR within 30 % of rGFR (P <subscript>30</subscript> ) value. Those two equations performed as well in older people as in the younger population. The CKD-EPI <subscript>scr-cys</subscript> equation acquired the highest P <subscript>30</subscript> (80.9 %) in subgroups with rGFR ≥60 mL/min/1.73 m <superscript>2</superscript> , while the CKD-EPI <subscript>cys</subscript> equation yielded the best performance in the rGFR <60 mL/min/1.73 m <superscript>2</superscript> subgroup.<br />Conclusion: CKD-EPI <subscript>scr-cys</subscript> formula had better capability to accurately evaluate GFR in the participants CKD stages 1-2 in Chinese ethnic. The application of the cystatin C-based equations may be the optimal one for patients of moderately to severely injured GFR. Considering the accuracy in the entire range of participants less ideally, the additional of the Chinese racial factor is assumed to be essential.
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Area Under Curve
Asian People
Biomarkers blood
China
Female
Humans
Kidney diagnostic imaging
Male
Middle Aged
Predictive Value of Tests
ROC Curve
Radiopharmaceuticals administration & dosage
Renal Insufficiency, Chronic blood
Renal Insufficiency, Chronic ethnology
Renal Insufficiency, Chronic physiopathology
Reproducibility of Results
Technetium Tc 99m Pentetate administration & dosage
Creatinine blood
Cystatin C blood
Glomerular Filtration Rate
Kidney physiopathology
Models, Biological
Renal Insufficiency, Chronic diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7799
- Volume :
- 21
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 27125433
- Full Text :
- https://doi.org/10.1007/s10157-016-1273-9