Back to Search
Start Over
Patients With a History of Chemotherapy and Isolated del(20q) With Minimal Myelodysplasia Have an Indolent Course.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2016 Apr; Vol. 145 (4), pp. 459-66. Date of Electronic Publication: 2016 Mar 25. - Publication Year :
- 2016
-
Abstract
- Objectives: Isolated deletion (20q) is relatively common in myeloid neoplasms and has been rarely reported in cases of therapy-related myelodysplastic syndrome (MDS). Our aim was to characterize cases of isolated del(20q) in bone marrow biopsy specimens from patients with a history of chemotherapy with morphologic findings insufficient for a diagnosis of MDS.<br />Methods: In this retrospective study from one institution, we identified 22 patients with isolated del(20q) and no or minimal dysplasia and evaluated clinical and pathologic characteristics.<br />Results: Eleven of the patients had a history of chemotherapy for mostly lymphoproliferative disorders. There were no statistically significant differences in peripheral blood or bone marrow features between patients with a history of chemotherapy and those without. Three patients with a history of chemotherapy had died at last follow-up; cause of death was recurrent nonmyeloid neoplasm. None of the patients with a history of chemotherapy subsequently developed a high-grade myeloid neoplasm, whereas one of the patients who had not received prior chemotherapy developed refractory anemia with excess blasts 2.<br />Conclusions: The presence of del(20q) as an isolated bone marrow cytogenetic abnormality in the absence of morphologic findings sufficient for a diagnosis of acute myeloid leukemia, myeloproliferative neoplasm, or MDS portends an indolent clinical course, regardless of previous exposure to chemotherapy.<br /> (© American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Agents adverse effects
Bone Marrow pathology
Chromosome Deletion
Female
Humans
In Situ Hybridization, Fluorescence
Kaplan-Meier Estimate
Male
Middle Aged
Myelodysplastic Syndromes chemically induced
Myelodysplastic Syndromes genetics
Retrospective Studies
Young Adult
Chromosomes, Human, Pair 20 genetics
Myelodysplastic Syndromes pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 145
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 27124938
- Full Text :
- https://doi.org/10.1093/ajcp/aqw024