Back to Search
Start Over
Sharing Structure and Function in Biological Design with SBOL 2.0.
- Source :
-
ACS synthetic biology [ACS Synth Biol] 2016 Jun 17; Vol. 5 (6), pp. 498-506. Date of Electronic Publication: 2016 May 04. - Publication Year :
- 2016
-
Abstract
- The Synthetic Biology Open Language (SBOL) is a standard that enables collaborative engineering of biological systems across different institutions and tools. SBOL is developed through careful consideration of recent synthetic biology trends, real use cases, and consensus among leading researchers in the field and members of commercial biotechnology enterprises. We demonstrate and discuss how a set of SBOL-enabled software tools can form an integrated, cross-organizational workflow to recapitulate the design of one of the largest published genetic circuits to date, a 4-input AND sensor. This design encompasses the structural components of the system, such as its DNA, RNA, small molecules, and proteins, as well as the interactions between these components that determine the system's behavior/function. The demonstrated workflow and resulting circuit design illustrate the utility of SBOL 2.0 in automating the exchange of structural and functional specifications for genetic parts, devices, and the biological systems in which they operate.
Details
- Language :
- English
- ISSN :
- 2161-5063
- Volume :
- 5
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ACS synthetic biology
- Publication Type :
- Academic Journal
- Accession number :
- 27111421
- Full Text :
- https://doi.org/10.1021/acssynbio.5b00215