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A method for direct in vivo measurement of drug concentrations from a single 2H NMR spectrum.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 1989 Mar; Vol. 9 (3), pp. 402-10. - Publication Year :
- 1989
-
Abstract
- The use of 2H-labeled drugs provides a measure of drug concentration in situ directly from a single 2H NMR spectrum obtained with any antenna by correcting only for differential saturation effects. The limit of detection for a drug labeled with three equivalent deuterons is roughly 0.5 mM.
Details
- Language :
- English
- ISSN :
- 0740-3194
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 2710006
- Full Text :
- https://doi.org/10.1002/mrm.1910090313