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Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).
- Source :
-
Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2016 May; Vol. 13 (5), pp. 261-80. Date of Electronic Publication: 2016 Apr 20. - Publication Year :
- 2016
-
Abstract
- Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bile Duct Neoplasms genetics
Bile Duct Neoplasms therapy
Cancer-Associated Fibroblasts physiology
Cell Proliferation physiology
Cell Transformation, Neoplastic genetics
Cholangiocarcinoma genetics
Cholangiocarcinoma therapy
Cytokines metabolism
Drug Resistance, Neoplasm genetics
Early Detection of Cancer
Epigenesis, Genetic genetics
Forecasting
Gene Fusion genetics
Genetic Heterogeneity
Humans
Intercellular Signaling Peptides and Proteins metabolism
Liver Transplantation
Macrophages physiology
Molecular Targeted Therapy methods
Neoplasm Proteins physiology
Neoplasm Staging
Neoplastic Stem Cells pathology
Receptor, Fibroblast Growth Factor, Type 2 genetics
Risk Factors
Signal Transduction genetics
Stents
Tumor Microenvironment genetics
Bile Duct Neoplasms pathology
Cholangiocarcinoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1759-5053
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature reviews. Gastroenterology & hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 27095655
- Full Text :
- https://doi.org/10.1038/nrgastro.2016.51