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Effect of Hydrogen Sulfide Donors on Intraocular Pressure in Rabbits.
- Source :
-
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2016 Jul-Aug; Vol. 32 (6), pp. 371-5. Date of Electronic Publication: 2016 Apr 19. - Publication Year :
- 2016
-
Abstract
- Purpose: In this study, we investigated the effect of a slow-releasing hydrogen sulfide (H2S) donor, GYY 4137, on intraocular pressure (IOP) in normotensive rabbits. Furthermore, we compared the IOP-lowering action of GYY 4137 with those elicited by other H2S-producing compounds, l-cysteine and ACS67 (a hybrid compound of latanoprost with an H2S-releasing moiety).<br />Methods: IOP was measured in New Zealand normotensive male albino rabbits using a pneumatonometer (model 30 classic; Reichert Ophthalmic Instruments, Depew, NY). At 0 h, 50 μL of test compounds were applied topically to 1 eye of each animal, while the contralateral eye received the same quantity of vehicle (saline). IOP was measured hourly until baseline IOP readings were attained and animal eyes monitored for potential side effects (i.e., tearing, hyperemia).<br />Results: GYY 4137 (0.1%-2%) produced a dose-dependent decrease in IOP reaching a maximum of 27.8% ± 3.14% (n = 5) after 6 h. Interestingly, a significant contralateral effect was observed in vehicle-treated controls eyes at all doses tested. l-cysteine (5%) and ACS67 (0.005%) also elicited a significant (P < 0.01) decrease in IOP that achieved a maximum of 28.84% ± 1.53% (n = 5) and 23.27% ± 0.51% (n = 5), respectively, after 3 h. All 3 H2S-producing compounds also caused a significant contralateral effect in vehicle-treated control eyes.<br />Conclusion: We conclude that GYY 4137 and other H2S-producing donors can reduce IOP in normotensive rabbits. However, the profile of IOP-lowering action of GYY 4137 was different from the other H2S donors affirming its ability to act as a slow-releasing gas donor.
- Subjects :
- Animals
Cysteine administration & dosage
Dose-Response Relationship, Drug
Male
Morpholines administration & dosage
Organothiophosphorus Compounds administration & dosage
Prostaglandins F, Synthetic administration & dosage
Rabbits
Thioctic Acid administration & dosage
Thioctic Acid pharmacology
Cysteine pharmacology
Intraocular Pressure drug effects
Morpholines pharmacology
Organothiophosphorus Compounds pharmacology
Prostaglandins F, Synthetic pharmacology
Thioctic Acid analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7732
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 27092593
- Full Text :
- https://doi.org/10.1089/jop.2015.0144