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The Molecular Registry of Pituitary Adenomas (REMAH): A bet of Spanish Endocrinology for the future of individualized medicine and translational research.
- Source :
-
Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion [Endocrinol Nutr] 2016 Jun-Jul; Vol. 63 (6), pp. 274-84. Date of Electronic Publication: 2016 Apr 16. - Publication Year :
- 2016
-
Abstract
- Pituitary adenomas are uncommon, difficult to diagnose tumors whose heterogeneity and low incidence complicate large-scale studies. The Molecular Registry of Pituitary Adenomas (REMAH) was promoted by the Andalusian Society of Endocrinology and Nutrition (SAEN) in 2008 as a cooperative clinical-basic multicenter strategy aimed at improving diagnosis and treatment of pituitary adenomas by combining clinical, pathological, and molecular information. In 2010, the Spanish Society of Endocrinology and Nutrition (SEEN) extended this project to national level and established 6 nodes with common protocols and methods for sample and clinical data collection, molecular analysis, and data recording in a common registry (www.remahnacional.com). The registry combines clinical data with molecular phenotyping of the resected pituitary adenoma using quantitative real-time PCR of expression of 26 genes: Pituitary hormones (GH-PRL-LH-FSH-PRL-ACTH-CGA), receptors (somatostatin, dopamine, GHRH, GnRH, CRH, arginine-vasopressin, ghrelin), other markers (Ki67, PTTG1), and control genes. Until 2015, molecular information has been collected from 704 adenomas, out of 1179 patients registered. This strategy allows for comparative and relational analysis between the molecular profile of the different types of adenoma and the clinical phenotype of patients, which may provide a better understanding of the condition and potentially help in treatment selection. The REMAH is therefore a unique multicenter, interdisciplinary network founded on a shared database that provides a far-reaching translational approach for management of pituitary adenomas, and paves the way for the conduct of combined clinical-basic innovative studies on large patient samples.<br /> (Copyright © 2016 SEEN. Published by Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Adenoma chemistry
Adenoma genetics
Adolescent
Adult
Aged
Child
Databases, Factual
Endocrinology trends
Female
Gene Expression Profiling
Genetic Association Studies
Humans
Male
Middle Aged
Molecular Biology
Neoplasm Proteins analysis
Neoplasm Proteins genetics
Pituitary Hormones analysis
Pituitary Hormones genetics
Pituitary Neoplasms chemistry
Pituitary Neoplasms genetics
RNA, Neoplasm genetics
Real-Time Polymerase Chain Reaction
Receptors, Pituitary Hormone analysis
Receptors, Pituitary Hormone genetics
Societies, Medical
Spain epidemiology
Young Adult
Adenoma epidemiology
Endocrinology organization & administration
Pituitary Neoplasms epidemiology
Precision Medicine trends
Registries
Translational Research, Biomedical trends
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1579-2021
- Volume :
- 63
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion
- Publication Type :
- Academic Journal
- Accession number :
- 27091627
- Full Text :
- https://doi.org/10.1016/j.endonu.2016.03.001