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The relationship between serum lectin-like oxidized LDL receptor-1 levels and systolic heart failure.
- Source :
-
Acta cardiologica [Acta Cardiol] 2016 Apr; Vol. 71 (2), pp. 185-90. - Publication Year :
- 2016
-
Abstract
- Objectives: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1’s relationship with serum pro-brain natriuretic peptide (NT-proBNP).<br />Design and Settings: This was a cross-sectional study of all eligible patients admitted to the department of cardiology of the University Hospital between July 2011 and April 2012.<br />Methods: Fifty-five patients with a diagnosis of systolic heart failure and 25 patients without systolic HF were enrolled in this study. Serum C-reactive protein, NT-proBNP, and LOX-1 were studied.<br />Results: Serum LOX-1 and NT-proBNP levels were significantly higher in the heart failure group and showed a positive correlation with NT-proBNP and negative correlations with left ventricular ejection fraction (EF). In addition, LOX-1 levels in patients with ischaemic cardiomyopathy were significantly higher, while they were similar in patients with dilated cardiomyopathy compared to control subjects.<br />Conclusion: Our study demonstrates the utility of the serum LOX-1 levels in the diagnosis of left ventricular systolic heart failure. LOX-1 may have a place in the diagnosis of heart failure, in particular in patients with ischaemic cardiomyopathy.
- Subjects :
- Aged
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Prognosis
Reproducibility of Results
Statistics as Topic
Stroke Volume
Turkey
Heart Failure, Systolic blood
Heart Failure, Systolic diagnosis
Heart Failure, Systolic physiopathology
Natriuretic Peptide, Brain blood
Peptide Fragments blood
Scavenger Receptors, Class E blood
Ventricular Dysfunction, Left physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5385
- Volume :
- 71
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta cardiologica
- Publication Type :
- Academic Journal
- Accession number :
- 27090040
- Full Text :
- https://doi.org/10.2143/AC.71.2.3141848