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The polymorphisms of MSH6 gene are associated with AIDS progression in a northern Chinese population.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2016 Aug; Vol. 42, pp. 9-13. Date of Electronic Publication: 2016 Apr 16. - Publication Year :
- 2016
-
Abstract
- It has been reported that DNA repair genes play an important role in HIV-1 infection and AIDS progression. One DNA repair pathway, the mismatch repair (MMR) is associated with a wide variety of tumors. However, the role of single nucleotide polymorphisms (SNPs) in the MMR genes and their importance in HIV-1 infection and AIDS progression remain unclear. In the present study, 479 HIV-1-infected and 487 healthy individuals from northern China were genotyped for nine SNPs in the MSH2 gene (rs13019654, rs4608577, rs4952887, rs6726691, rs10191478, rs12999145, rs1981929, rs2042649, rs2303428) and five SNPs in the MSH6 gene (rs2348244, rs3136245, rs3136329, rs2072447, rs7562048). Our results showed that the rs7562048 G allele frequency was significantly higher in the cases with the CD4(+) T-lymphocyte count <200cells/μl than those with >200cells/μl (P=0.001, OR=1.811, 95% CI 1.255-2.614), which is in agreement with the result of the Bonferroni correction. The frequencies of the rs2348244 C allele and rs3136245 T allele were higher in the cases at clinical phase IV than those at clinical phase I+II+III (P=0.026, OR=1.591, 95% CI 1.056-2.398 and P=0.019, OR=1.749, 95% CI 1.096-2.791, respectively); however, this difference is not supported by the Bonferroni correction. There were no significant differences in the frequency of allele, genotype and haplotype of the 14 SNPs between HIV-1-infected individuals and healthy controls (P>0.05). These results suggest that the rs7562048 is associated with the clinical features and that the MSH6 gene polymorphisms likely play an important role in the progression of AIDS in the northern Chinese population.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Acquired Immunodeficiency Syndrome ethnology
Acquired Immunodeficiency Syndrome immunology
Acquired Immunodeficiency Syndrome pathology
Adolescent
Adult
Aged
Alleles
Asian People
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes pathology
Case-Control Studies
Clinical Trials as Topic
DNA-Binding Proteins immunology
Disease Progression
Gene Expression
Gene Frequency
HIV-1 pathogenicity
Haplotypes
Homosexuality, Male
Humans
Male
Middle Aged
Acquired Immunodeficiency Syndrome genetics
CD4-Positive T-Lymphocytes virology
DNA-Binding Proteins genetics
Genetic Predisposition to Disease
HIV-1 physiology
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 42
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 27090025
- Full Text :
- https://doi.org/10.1016/j.meegid.2016.04.016