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Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 May 13; Vol. 473 (4), pp. 1268-1275. Date of Electronic Publication: 2016 Apr 13. - Publication Year :
- 2016
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Abstract
- Long non-coding RNAs (lncRNAs) had been proved to be pivotal regulators in carcinogenesis. On the basis of competitive endogenous RNAs (ceRNAs) system, lncRNAs significantly expanded their regulating networks. In our research, we aimed to figure out the exact role of lncRNA HNF1A-AS1 in the pathogenesis of hepatocellular carcinoma (HCC), in a ceRNA-dependent way. First, we revealed: HNF1A-AS1 was frequently overexpressed in HCC tissues and cell lines and its relative high expression was closely related to larger tumor size, multiple tumor lesions, poor differentiation and advanced TNM stage. Then we found: HNF1A-AS1 functioned as an oncogene in tumor growth and apoptosis through sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2. Further experiments identified: HNF1A-AS1-miR-30b axis significantly promoted autophagy under starvation and ATG5 was first proved to be a target of miR-30b. In summary, we identified HNF1A-AS1-miR-30b axis as a key regulator in hepatocarcinogenesis, which may be promising biomarkers and therapeutic targets in the future.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Carcinoma, Hepatocellular pathology
Gene Expression Regulation, Neoplastic genetics
Humans
Liver Neoplasms pathology
Oncogenes genetics
Promoter Regions, Genetic
Tumor Cells, Cultured
Autophagy genetics
Carcinoma, Hepatocellular genetics
Hepatocyte Nuclear Factor 1-alpha genetics
Liver Neoplasms genetics
MicroRNAs genetics
RNA, Long Noncoding genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 473
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 27084450
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.04.054