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A Theranostic Two-Tone Luminescent PhotoCORM Derived from Re(I) and (2-Pyridyl)-benzothiazole: Trackable CO Delivery to Malignant Cells.
- Source :
-
Inorganic chemistry [Inorg Chem] 2016 Aug 15; Vol. 55 (16), pp. 7852-8. Date of Electronic Publication: 2016 Apr 15. - Publication Year :
- 2016
-
Abstract
- A Re(I) carbonyl complex derived from 2-(2-pyridyl)-benzothiazole (pbt), [Re(H2O)(CO)3(pbt)](CF3SO3) (1), rapidly releases CO under low-power UV illumination. CO photorelease from 1 is accompanied by a change in luminescence from orange to deep blue. These two distinct luminescence signals have been successfully employed to track (a) the entry of the pro-drug 1 into cancer cells and (b) the end of the CO (drug) delivery step within the target.
- Subjects :
- Benzothiazoles chemistry
Breast Neoplasms therapy
Cell Line, Tumor
Crystallography, X-Ray
Drug Carriers administration & dosage
Drug Carriers chemical synthesis
Drug Delivery Systems methods
Female
Humans
Luminescence
Magnetic Resonance Spectroscopy
Myoglobin metabolism
Prodrugs administration & dosage
Pyridines chemistry
Spectrometry, Fluorescence
Carbon Monoxide administration & dosage
Drug Carriers chemistry
Organometallic Compounds chemistry
Rhenium chemistry
Theranostic Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1520-510X
- Volume :
- 55
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Inorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27082125
- Full Text :
- https://doi.org/10.1021/acs.inorgchem.6b00511