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Longitudinal assessment of subcortical gray matter volume, cortical thickness, and white matter integrity in HIV-positive patients.
- Source :
-
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2016 Nov; Vol. 44 (5), pp. 1262-1269. Date of Electronic Publication: 2016 Apr 15. - Publication Year :
- 2016
-
Abstract
- Purpose: To longitudinally evaluate the cortical thickness and deep gray matter structures volume, measured from T1 three-dimensional (3D) Gradient echo-weighted imaging, and white matter integrity, assessed from diffusion tensor imaging (DTI) of HIV-positive patients.<br />Materials and Methods: Twenty-one HIV-positive patients on stable highly active antiretroviral therapy (HAART) with CD4+ T lymphocytes count >200 cells/mL and viral load <50 copies/mL underwent two magnetic resonance imaging (MRI) scans with a median interval of 26.6 months. None of the patients had HIV-related dementia. T1 3D magnetization prepared rapid gradient echo-weighted imaging and DTI along 30 noncolinear directions were performed using a 1.5 Tesla MR scanner. FreeSurfer was used to perform cortical volumetric reconstruction and segmentation of deep gray matter structures. For tract-based spatial statistics analysis, a white matter skeleton was created, and a permutation-based inference with 5000 permutations, with a threshold of P < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The median, radial, and axial diffusivities were also projected onto the mean FA skeleton.<br />Results: There were no significant differences in cortical thickness, deep gray matter structures volumes or diffusivity parameters between scans at the two time points (considering P < 0.05).<br />Conclusion: No longitudinal differences in cortical thickness, deep gray matter volumes, or white matter integrity were observed in an HIV-positive population on stable HAART, with undetectable viral load and high CD4+ T lymphocytes count. J. Magn. Reson. Imaging 2016;44:1262-1269.<br /> (© 2016 International Society for Magnetic Resonance in Medicine.)
- Subjects :
- Adult
Antiretroviral Therapy, Highly Active methods
Encephalitis, Viral immunology
Female
Gray Matter immunology
HIV Infections immunology
Humans
Longitudinal Studies
Male
Middle Aged
Organ Size immunology
Treatment Outcome
Viral Load immunology
White Matter immunology
Diffusion Tensor Imaging methods
Encephalitis, Viral drug therapy
Encephalitis, Viral pathology
Gray Matter pathology
HIV Infections drug therapy
HIV Infections pathology
White Matter pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2586
- Volume :
- 44
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Publication Type :
- Academic Journal
- Accession number :
- 27079832
- Full Text :
- https://doi.org/10.1002/jmri.25263